WVUIT CHEMISTRY 451 SYLLABUS
Biochemistry
Spring 2005
Instructor: Dr. Jay Wiedemann, 3108 ORNH, 442-3135, jmwiedemann@wvutech.edu
Office Hours: Mon. 2:00-3:00 pm; Tue. 10:00-12:00; Thurs. 9:00-11:00
Additional time may be scheduled by appointment.
Lecture: Mon., Weds., and Fri, 1:00-1:50 pm, 3200 ORNH
Text: “Biochemistry ”, fifth edition, Stryer, L., Tymoczko, J.L., and Jeremy Berg 2003.
LEARNING OUTCOMES FOR CHEM 451
Students taking chemistry 451 will have an advanced knowledge of protein structure, function, and regulation as it relates to carbohydrate metabolism. The following is a list of specific topics covered in this course:
I) Proteins
A) Structure à Chapter 3
i) primary
ii) secondary
iii) tertiary
iv) quaternary
B) Protein Research Techniques à Chapter 4
i) protein purification
ii) immunology
iii) amino acid sequences
iv) three-dimensional structure
II) Enzymes
A) General Backgrounds à Chapter 8
i) thermodynamics
ii) active site
iii) Michaelis-Menten Model
iv) enzyme inhibition
B) Catalytic Strategies à Chapter 9
i) proteases
ii) carbonic anhydrases
iii) restriction enzymes
C) Regulatory à Chapter 10
i) allosteric regulators
ii) isozymes
iii) covalent modification
iv) proteolytic cleavage
III) Carbohydrates à Chapter 11
i) monosaccarides
ii) complex carbohydrate
iii) glycoproteins
iv) lectins
IV) A) Lipids and Cell Membranes à Chapter 12
i) biological membranes
ii) fatty acids
iii) phospholipids and glycolipids
iv) lipoproteins
v) specific compartments for metabolism
B) Membrane Channels and Ion Pumps à Chapter 13
i) membrane transporters
ii) gap juctions
V) Metabolism
A) Glycolysis and Gluconeogenesis à Chapter 16
i) glycolysis pathway
ii) gluconeogenesis
iii) regulation of I and ii
B) Citric acid Cycle à Chapter 17
C) Oxidative Phosphorylation à Chapter 18
D) Glycogen Metabolism à Chapter 21
VI) Transcription à handout
VII) Translation à handout
VIII) Replication à handout
Course Structure: The course is tentatively arranged so that chapters 3 through 13 and chapters 16, 17, and 21 will be covered during the semester. Four tests will be given throughout the semester, each covering three chapters. The final examination will be a comprehensive standardized test covering all of Biochemistry. Test dates will be announced at least two lecture periods ahead of time.
Grading: Makeup tests will be offered for excused absences only. If you have special circumstances, please let me know as far in advance as possible and I will attempt to accommodate you. Scores on tests will be subject to a normalization curve with the class average assigned as a 75; a middle C. Grades will be normalized to 100 points and will be assigned as follows:
90-100 pts. guarantees an A
80-89 pts. guarantees a B
70-79 pts. guarantees a C
60-69 pts. guarantees a D
< 60 pts. guarantees a F
Grading System
Four Hourly Exams 50%
Final Exam (Standardized Test) 15%
Research Paper 15%
Required Homework:
In order to develop a good understanding of the chemistry concepts taught in each class, it is required that the “In-Chapter Examples” which are part of the material covered in each lecture, are studied and understood. The problems that follow these examples are the homework assignment and are due at the start of next lecture.
Certain exercises at the end of each chapter, which are pertinent to the material covered in the lectures, will be assigned as homework and will be due at the start of the lecture following completion of the chapter.
Academic dishonesty (cheating) will not be tolerated. If you are caught cheating on a quiz or homework, you will receive a “0” for that assignment. If you are caught cheating on an exam, or on the final, you will receive an F for the entire course. All incidents of cheating will be reported to Academic Affairs.